Prediction of protein-protein interface sequence diversity using flexible backbone computational protein design
Description:
In an attempt to bypass the difficulty of the fact that proteins frequently change their conformation in response to mutations, the authors propose methods to approach effective protein design
Collection(s):
Resource Type:
Article
Creator:
Humphris EL, Kortemme T
Publisher:
Elsevier Ltd
All Collections Containing This Item
How are living things designed?
If thinking about synthetic biology as the application of engineering principles to biological systems, the engineering mind will break apart the process of DNA manipulation into a question of design. How are living things designed, and how can those designs be used and molded to perform functions that will result with the desired product? What models are synthetic biologists using as frameworks for their building? How does the question of design direct scientific study?