You're one in a googol: optimizing genes for protein expression
Description:
The authors describe past trends and results of studies of protein expression and suggest that synthetic biology may now provide the impetus to transform protein expression folklore into design principles, so that DNA sequences may easily be designed to express any protein in any system
Resource Type:
Article
Creator:
Welch, Mark, Alan Villalobos, Claes Gustafsson and Jeremy Minshull
Publisher:
Journal of the Royal Society
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How do we "engineer life" effectively with our incomplete knowledge of biology?
Synthetic biology has many definitions, one including the claim that its goal is to "engineer novel life systems." It is with this goal that part of the emerging discipline's platform is to do for biology what electrical engineering did for the study of circuits and electrons: to standardize strands of DNA that produce proteins with known functions so that they can be manipulated and recombined in a novel way.