Publications

Publications related to synthetic biology. Includes scientific journal publications and popular press publications.

Resources in this collection

MIT Labs (Knight & Endy)
Adventures in Synthetic Biology: Treating Cancer with E. coli
Jay Keasling combats global challenges with biotechnology
Analysis of metabolic pathways and fluxes in a newly discovered thermophilic and ethanol-tolerant Geobacillus strain
Native state energetics of the Src SH2 domain: evidence for a partially structured state in the denatured ensemble
Engineering microbes with synthetic biology frameworks
DESHARKY: automatic design of metabolic pathways for optimal cell growth
De novo biosynthetic pathways: rational design of microbial chemical factories
High-titer production of monomeric hydroxyvalerates from levulinic acid in Pseudomonas putida
Can we learn to program DNA and living organisms as well as or better than we currently program computers?
Engineering Biology: A Talk with Drew Endy
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
An efficient recombination system for chromosome engineering in Escherichia coli
Synthetic biology: new engineering rules for an emerging discipline
Synthetic Biology
Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization
Towards synthesis of a minimal cell
Noise in transcription negative feedback loops: simulation and experimental analysis
Accurate prediction of gene feedback circuit behavior from component properties
Programming gene expression with combinatorial promoters
A synthetic oscillatory network of transcriptional regulators
Towards Logical Designs in Biology
Genetic design: rising above the sequence
The economics of synthetic biology
A synthetic genetic circuit to implement a Schmitt Trigger in E. Coli
Synthetic biologists face up to security issues
Intricate interactions within the ccd Plasmid Addiction System
Following translation by single ribosomes one codon at a time
Stochastic dynamics of macromolecular-assembly networks
The application of Tet repressor in prokaryotic gene regulation and expression (review)
Genetic parts to program bacteria
Synthetic biology: engineering Escherichia coli to see light
Accessible Science
Amateurs are trying genetic engineering at home
Project SmartLab
Project BioweatherMaps
Project DIYiGEM 2009
People to Watch: Jay Keasling -- Saving the World One Molecule at a Time
How to Make Life: Drew Endy
75 Most Influential People of the 21st Century: Jay Keasling
How the Personal Genome Project Could Unlock the Mysteries of Life
An affordable way to treat malaria
Superbugs May Save Biofuels
Sweet New Fuel
Constructing Life Creates Questions of Ethics
Supergene Labs Design Microbes to Change Sun to Fuel, Eat Waste
Faces of 2007: Drew Endy, leader in synthetic biology
As DNA research advances, science plays God ever more
Genetic Engineering Competitors Create Modular DNA Dev Kit
English, Algebra, Phys Ed ... and Biotech
High school biowizards break new ground in winning competition
Emeryville biofuels crib to see how plants can fuel vehicles
Jay Keasling Combats Global Challenges with Biotechnology
New Policy Report Outlines Options for Governance of Synthetic Genomics
First, Cure Malaria. Next, Global Warming.
TR35 2007 Young Innovator: Christopher Anderson
TR35 2007 Young Innovator: Kristala Jones Prather
DISCOVER Magazine Names Jay Keasling Its First Annual Scientist of the Year
Architect of Life
The Quest for the $1,000 Human Genome
Extreme Genetic Engineering: An Introduction to Synthetic Biology
Life 2.0
Life 2.0: Scientists push the boundaries of Human Life
Biology by design: reduction and synthesis of cellular components and behaviour
Systems biology as a foundation for genome-scale synthetic biology
A perspective of synthetic biology: assembling building blocks for novel functions.
A synthetic oscillatory network of transcriptional regulators
Construction of a genetic toggle switch in <i>Escherichia coli</i>
Balancing a heterologous mevalonate pathway for improved isoprenoid production in <i>Escherichia coli. </i>
Production of isoprenoid pharmaceuticals by engineered microbes
Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria
DNA Synthesis and biological security
Life: What a Concept (part III)
Bio Building Basics: A Conceptual Instruction Manual for Synthetic Biology
Primer for Synthetic Biology (Draft)
The Evolution of Two-Component Systems in Bacteria Reveals Different Strategies for Niche Adaptation
Environmentally controlled invasion of cancer cells by engineered bacteria
Environmental signal integration by a modular AND gate
Simulating cell biology
A mechanical explanation for cytoskeletal rings and helices in bacteria
Systems biology: a switch for sex
Setting the standard in synthetic biology
Fast, cheap and somewhat in control
Analysis of a ferric uptake regulator (Fur) mutant of Desulfovibrio vulgaris Hildenborough
Cellular response of Shewanella oneidensis to strontium stress
Global analysis of heat shock response in Desulfovibrio vulgaris Hildenborough
Environmental genomics reveals a single-species ecosystem deep within Earth
Temporal transcriptomic analysis as Desulfovibrio vulgaris Hildenborough transitions into stationary phase during electron donor depletion
Genomics for environmental microbiology
Model discrimination using data collaboration
A dual receptor crosstalk model of g-protein-coupled signal transduction
A tightly regulated inducible expression system utilizing the fim inversion recombination switch
Design and construction of a double inversion recombination switch for heritable sequential genetic memory
Energetic consequences of nitrite stress in Desulfovibrio vulgaris Hildenborough, inferred from global transcriptional analysis
Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants
RegTransBase--a database of regulatory sequences and interactions in a wide range of prokaryotic genomes
Comparative Genomics of Regulation of Fatty Acid and Branched-chain Amino Acid Utilization in Proteobacteria
Transcriptome profiling of Shewanella oneidensis gene expression following exposure to acidic and alkaline pH
Toward scalable parts families for predictable design of biological circuits
Salt stress in Desulfovibrio vulgaris Hildenborough: an integrated genomics approach
Cell-wide responses to low-oxygen exposure in Desulfovibrio vulgaris Hildenborough
Morphology matters in immune cell chemotaxis: membrane asymmetry affects amplification
Global analysis of host response to induction of a latent bacteriophage
Averaging Methods for Stochastic Dynamics of Complex Reaction Networks: Description of Multiscale Couplings
The histidine operon is ancient
The life-cycle of operons
OpWise: operons aid the identification of differentially expressed genes in bacterial microarray experiments
Orthologous transcription factors in bacteria have different functions and regulate different genes
Horizontal gene transfer and the evolution of transcriptional regulation in Escherichia coli
Deviant effects in molecular reaction pathways
Response of Desulfovibrio vulgaris to alkaline stress
Genetics and Genomics of Sulfate Respiration in Desulfovibrio
Memory in microbes: quantifying history-dependent behavior in a bacterium
Exploring subdomain cooperativity in T4 lysozyme I: structural and energetic studies of a circular permutant and protein
A Ras-induced conformational switch in the Ras activator Son of sevenless
FDA Teams with WebMD for New Online Consumer Health Information
Improving Our Ability To Peek Inside Molecules
IASB Workshop: Technical Solutions for Biosecurity in Synthetic Biology
Nietzsche, Genealogy, History
What is Critique?
"Omnes et Singulatim": Toward a Critique of Political Reason
Life, Experience and Science
What is Enlightenment?
What is Revolution?
An Integrated Approach to Oversight Assessment for Emerging Technologies
Nanotube Producing Bacteria show manufacturing promise.
PLANNING FOR CONTACT: FANTASY DOCUMENTS OR GUIDELINES FOR ACTION?
Corporate Preparedness for Pandemic Influenza: A Survey of Pharmaceutical and Biotechnology Companies in Montgomery County, Maryland
Waiving EMTALA Sanctions in Response to Public Health Emergencies
Ethics and Severe Pandemic Influenza: Maintaining Essential Functions through a Fair and Considered Response
Why Do UK Military Personnel Refuse the Anthrax Vaccination?
Missouri Nurses' Bioterrorism Preparedness
Willingness of New England Dental Professionals to Provide Assistance during a Bioterrorism Event
Strengthening Biodefense Internationally: Illusion and Reality
Panel warns of unconventional terror attacks
Lieberman to Seek Tougher Regulations for Biological Research Labs
Pig Ebola may lead scientists to 'Elusive Resorvoir' of Virus
Next NIH Director Faces Budget Issues
Hatfill Rejected by Top U S Court on New York Times Libel Suit
Detrick presents opportunities for Washington Co.
Detrick a lifeline for area businesses
Federal Research Plan Inadequate to Shed Light on Health and Environmental Risks Posed by Nanomaterials
FDA Reports Significant Progress in Protecting the Food Supply
Homeland Security Council Planning Scenario Envisions Anthrax Attacks on Multiple Cities
Defending Against Weapons of Mass Destruction Terrorism Commission Report Endorses Administration Initiatives and Calls for Continuation of Successful WMD Policies to Address Increasing Threat
US panel presents sobering report on WMD threat
Obama to create WMD Threat Post
Nuclear or Bioterror Attack on U.S. Likely by 2013, Panel Warns
Biological terror attack likely by 2013, panel says
WMD Panel Releases Report to Congress: World at Risk Nuclear and Biological Weapons Pose Greatest Peril
Government recommends Kansas for biodefense lab
Bioterror Trumps Nuclear Threat
Army labs get security training after anthrax case
Energetics-based protein profiling on a proteomic scale: identification of proteins resistant to proteolysis
Microbial oxidation of naphthalene to cis-1,2-naphthalene dihydrodiol using naphthalene dioxygenase in biphasic media
Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers
Polony DNA sequencing
Synthetic biology projects in vitro
The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency
Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
Synthetic biology: lessons from the history of synthetic organic chemistry
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
Engineering synthetic signaling proteins with ultrasensitive input/output control
Engineering modular protein interaction switches by sequence overlap
Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP
Beta strand peptidomimetics as potent PDZ domain ligands
Docking interactions in protein kinase and phosphatase networks
Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits
Environmental signal integration by a modular AND gate
Engineered protein connectivity to actin mimics PDZ-dependent recycling of G Protein-coupled Receptors but not its regulation by Hrs
Bacteria subsisting on antibiotics
Gene synthesis by circular assembly amplification
A new twist in TCR diversity revealed by a forbidden alphabeta TCR
Structural mapping of protein interactions reveals differences in evolutionary pressures correlated to mRNA level and pr
Mutations designed to destabilize the receptor-bound conformation increase MICA-NKG2D association rate and affinity
Design of multi-specificity in protein interfaces
A Ras-induced conformational switch in the Ras activator Son of sevenless
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease
Metabolic engineering of microorganisms for biofuels production: from bugs to synthetic biology to fuels
Membrane proteomics of phagosomes suggests a connection to autophagy
Developing Aspergillus as a host for heterologous expression
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
Environmentally controlled invasion of cancer cells by engineered bacteria
Metabolic engineering of microorganisms for isoprenoid production
Printable view Expression of a synthetic <i>Artemesia annua</i> amorphadiene synthase in <i>Aspergillus nidulans</i> yields altered product distribution Expression of a synthetic Artemesia annua amorphadiene synthase in Aspergillus nidulans yields altere
Heterologous protein production in Escherichia coli using the propionate-inducible pPro system by conventional and auto-induction methods
Redesigning Enzymes Based on Adaptive Evolution for Optimal Function in Synthetic Metabolic Pathways
Importance of systems biology in engineering microbes for biofuel production
Biofuel alternatives to ethanol: pumping the microbial well
Post-translational modifications of Desulfovibrio vulgaris Hildenborough sulfate reduction pathway proteins
Application of functional genomics to pathway optimization for increased isoprenoid production
Metabolic engineering delivers next-generation biofuels
Backrub-Like Backbone Simulation Recapitulates Natural Protein Conformational Variability and Improves Mutant Side-Chain
Reports and Recommendations: Research on the fetus
Reports and Recommendations: Research involving prisoners
Reports and Recommendations: Research involving children
Reports and Recommendations: Psychosurgery
Reports and Recommendations: Ethical Guidelines for the Delivery of Health Services by DHEW
Appendix to Ethical Guidelines for the Delivery of Health Services by DHEW
Defining Death: Medical, Legal, and Ethical Issues in the Determination of Death
IRB (Institutional Review Board) Guidebook
Compensating for Reseach Injuries: The Ethical and Legal Implications of Programs to Redress Injured Subjects: Volume One Report
Deciding to Forego Life-Sustaining Treatment: Ethical, Medical and Legal Issues in Treatment Decisions
Screening and Counseling for Genetic Conditions: A report on the Ethical, Social, and Legal Implications of Genetic Screening, Counseling, and Education Programs
Securing Access to Health Care: The Ethical Implications of Differences in the Availability of Health Services
Summing Up: The Ethical and Legal Problems in Medicine and Biomedical and Behavorial Research
Report of the Human Embryo Research Panel: Volume I
Report of the Human Embryo Research Panel: Volume II
Cloning Human Beings: Report and Recommendations of the National Bioethics Advisory Commission
Research Involving Persons with Mental Disorders That May Affect Decisionmaking Capacity
Research Involving Human Biological Materials: Ethical Issues and Policy Guidance
Ethical Issues in Human Stem Cell Research: Volume III: Religious Perspectives
Ethical Issues in Human Stem Cell Research: Volume II: Commissioned Papers
Ethical and Policy Issues in International Research: Clinical Trials in Developing Countries
Ethical and Policy Issues in Research Involving Human Participants
Human Cloning and Human Dignity: An ethical inquiry
Beyond Therapy: Biotechnology and the Pursuit of Happiness
Being Human: Readings from the President's Council on Bioethics
Monitoring Stem Cell Research
White Paper: Alternative Sources of Pluripotent Cells
Taking Care: Ethical Caregiving in our Aging Society
Authentic teaching and learning through synthetic biology
Induction and relaxation dynamics of the regulatory network controlling the type III secretion system encoded within Salmonella pathogenicity island 1
Efficient microRNA capture and bar-coding via enzymatic oligonucleotide adenylation
Quantitative determination of protein stability and ligand binding by pulse proteolysis
The emerging world of wikis
Gene synthesis demystified
7A projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals
Stimulus design for model selection and validation in cell signaling
TABASCO: A single molecule, base-pair resolved gene expression simulator
Synthetic genomics - options for governance
DNA synthesis and biological security
Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability
Ebola outbreak has experts rooting for answers
A CDC Report on Terrorism Preparedness and Emergency Response (TPER) -- Funded Activities
Science tipped to score in Obama cash stimulus
Cash boost for US science
Al Qaeda bungles arms experiment
Al Qaeda reportedly suffers WMD Mishap
CDC Warns of Program Cuts
Plum Island Animal Disease Center set to close in 2015
The Center for Biosecurity Commends the New Obama Administration's Commitment to Strengthening Biosecurity
Crisis communication
Bush established Laboratory Biosecurity Panel
Experts Debate Threat of Nuclear Biological Terrorism
January 1 Attack by CIA killed two leaders of Al Qaeda
Kansas Site Gets Final OK to Host Biological Defense Lab
Senior U.S. Counterterrorism Officials Differ Over Al-Qaeda Threat
U.S. Refuses Israeli Requests for Support of Iran Attacks
Critics Question Army Readiness for Post-WMD-Attack Domestic Patrols
Preventing a Resident Evil Scenario
Researchers use nanoparticles to make 3-D DNA nanotubes
Artificial molecule evolves in the lab
CEN Workshop 31 - Laboratory Biosafety and Biosecurity
Restricting the role of biosecurity
TFAH releases annual 'Ready or Not' Report
Draft of National Vaccine Plan Released
NSABB Discusses Lab Personnel Reliability
Southern Research Institute wins $37 Million Black & Veatch Sub-Contract for Biological Threat Reduction Program
FSIS Seeks Comments On Draft Risk Assessment For The Public Health Impact Of Highly Pathogenic Avian Influenza Virus In Poultry, Shell Eggs, And Egg Products
Biosafety, Biosecurity, and Preparedness
Rise of the garage genome hackers